CACTVS System: - A distributed client/server system for the computation, management, analysis and visualization of chemical information of any type. Tool collection for several Unix flavors; some of the tools are distributed freely in precompiled form.
Frowns: - Free chemoinformatics toolkit geared toward rapid development of chemistry related algorithms. Written in Python with a small portion written in C++.
JChem: - A Java based development tool for building portable chemical information systems.
Jumbo: - Free kit for processing XML+CML in chemistry. Java 1.4 code, XSLT stylesheets, legacy converters and tools. Also includes tools for generating C++, Python and some F90/5 from the schema.
Open Babel: - Open-source C++ library for molecule file conversion and pattern matching.
pdb2vrml: - Free C++ library for converting Protein Data Bank (PDB) files to Virtual Reality Modeling Language (VRML) worlds.
PerlMol: - Free Perl modules for molecular chemistry. Tutorial, reference manual, downloads and mailing list.
Software Development Lohninger: - Software and programming components for Delphi and C++Builder covering mathematics, statistics, scientific graphing, and chemistry.
